Organ Care System (OCS) Publications
Access the large and growing repository of OCS publications to gain greater insight into our substantial body of clinical evidence
LUNG
Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial
Gabriel Loor, MD, Prof Gregor Warnecke, MD, Mauricio A Villavicencio, MD, Michael A Smith, MD, Prof Jasleen Kukreja, MD, Prof Abbas Ardehali, MD, Matthew Hartwig, MD Mani A Daneshmand, MD, Prof Marshall I Hertz, MD, Stephen Huddleston, MD, Prof Axel Haverich, MD, Prof Joren C Madsen, MD, Prof Dirk Van Raemdonck, MD. The Lancet (2019). DOI:https://doi.org/10.1016/S2213-2600(19)30200-0.
Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study
Prof Gregor Warnecke, MD, Prof Dirk Van Raemdonck, MD, Michael A Smith, MD, Gilbert Massard, MD, Jasleen Kukreja, MD, Prof Federico Rea, MD, Gabriel Loor, MD, Fabio De Robertis, MD, Jayan Nagendran, MD, Prof Kumud K Dhital, MD, Francisco Javier Moradiellos Díez, MD, Christoph Knosalla, MD, Christian A Bermudez, MD, Steven Tsui, MD, Kenneth McCurry, MD, I-Wen Wang, MD, Prof Tobias Deuse, MD, Guy Lesèche, MD, Pascal Thomas, MD, Igor Tudorache, MD, Christian Kühn, MD, Murat Avsar, MD, Bettina Wiegmann, MD, Wiebke Sommer, MD, Prof Arne Neyrinck, MD, Marco Schiavon, MD. Prof Fiorella Calabrese, MD, Nichola Santelmo, MD, Anne Olland, MD, Pierre-Emanuel Falcoz, MD, Andre R Simon, MD, Prof Andres Varela, MD, Joren C Madsen, MD, Marshall Hertz, MD, Prof Axel Haverich, MD, Prof Abbas Ardehali, MD. The Lancet (2018). DOI:https://doi.org/10.1016/S2213-2600(18)30136-X.
Results of the OCS Lung EXPAND International Trial Using Portable Normothermic OCS Lung Perfusion System (OCS) to Recruit and Evaluate Extended Criteria Donor (ECD) Lungs
G. Loor, G. Warnecke, M. Villavicencio, M. Smith, J. Kukreja, A. Ardehali, M. Hartwig, M. Daneshmand, M. Hertz, A. Haverich, J. Madsen, D. Van Raemdonck. Journal of Heart and Lung Transplantation (2018). DOI:https://doi.org/10.1016/j.healun.2018.01.356.
Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial
Gabriel Loor, MD, Prof Gregor Warnecke, MD, Mauricio A Villavicencio, MD, Michael A Smith, MD, Prof Jasleen Kukreja, MD, Prof Abbas Ardehali, MD, Matthew Hartwig, MD Mani A Daneshmand, MD, Prof Marshall I Hertz, MD, Stephen Huddleston, MD, Prof Axel Haverich, MD, Prof Joren C Madsen, MD, Prof Dirk Van Raemdonck, MD. The Lancet (2019). DOI:https://doi.org/10.1016/S2213-2600(19)30200-0.
Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study
Prof Gregor Warnecke, MD, Prof Dirk Van Raemdonck, MD, Michael A Smith, MD, Gilbert Massard, MD, Jasleen Kukreja, MD, Prof Federico Rea, MD, Gabriel Loor, MD, Fabio De Robertis, MD, Jayan Nagendran, MD, Prof Kumud K Dhital, MD, Francisco Javier Moradiellos Díez, MD, Christoph Knosalla, MD, Christian A Bermudez, MD, Steven Tsui, MD, Kenneth McCurry, MD, I-Wen Wang, MD, Prof Tobias Deuse, MD, Guy Lesèche, MD, Pascal Thomas, MD, Igor Tudorache, MD, Christian Kühn, MD, Murat Avsar, MD, Bettina Wiegmann, MD, Wiebke Sommer, MD, Prof Arne Neyrinck, MD, Marco Schiavon, MD. Prof Fiorella Calabrese, MD, Nichola Santelmo, MD, Anne Olland, MD, Pierre-Emanuel Falcoz, MD, Andre R Simon, MD, Prof Andres Varela, MD, Joren C Madsen, MD, Marshall Hertz, MD, Prof Axel Haverich, MD, Prof Abbas Ardehali, MD. The Lancet (2018). DOI:https://doi.org/10.1016/S2213-2600(18)30136-X.
Results of the OCS Lung EXPAND International Trial Using Portable Normothermic OCS Lung Perfusion System (OCS) to Recruit and Evaluate Extended Criteria Donor (ECD) Lungs
G. Loor, G. Warnecke, M. Villavicencio, M. Smith, J. Kukreja, A. Ardehali, M. Hartwig, M. Daneshmand, M. Hertz, A. Haverich, J. Madsen, D. Van Raemdonck. Journal of Heart and Lung Transplantation (2018). DOI:https://doi.org/10.1016/j.healun.2018.01.356.
Normothermic donor heart perfusion: current clinical experience and the future.
Simon Messer, Abbas Ardehali, Steven Tsui. Transplant International (2014). DOI:10.1111/tri.12361.
Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System Lung before bilateral transplantation: a pilot study of 12 patients
Dr Gregor Warnecke, MD, Javier Moradiellos, MD, Igor Tudorache, MD, Christian Kühn, MD, Murat Avsar, MD, Bettina Wiegmann, MD, Wiebke Sommer, MD, Fabio Ius, MD, Claudia Kunze, CTRN, Jens Gottlieb, MD, Prof Andres Varela, MD, Prof Axel Haverich, MD. The Lancet (2012). DOI:https://doi.org/10.1016/S0140-6736(12)61344-0.
Utilization of the Organ Care System Lung for the assessment of lungs from a donor after cardiac death (DCD) before bilateral transplantation
PN Mohite, A Sabashnikov, D García Sáez, B Pates, M Zeriouh, F De Robertis, and AR Simon. Perfusion (2014). DOI:https://doi.org/10.1177/02676591145571.
Lung transplantation from donors after circulatory death using portable ex vivo lung perfusion
Sabin Bozso, BSc, Vishnu Vasanthan, Jessica GY Luc, Katie Kinaschuk, Darren Freed, MD PhD, and Jayan Nagendran, MD PhD. Canadian Respiratory Journal (2015). DOI: 10.1155/2015/357498.
Long-term results after lung transplantation using organs from circulatory death donors: a propensity score-matched analysis
Anton Sabashnikov, Nikhil P. Patil, Aron-Frederik Popov, Simona Soresi, Bartlomiej Zych, Alexander Weymann, Prashant N. Mohite, Diana García Sáez, Mohamed Zeriouh, Thorsten Wahlers, Yeong-Hoon Choi, Jens Wippermann, Thorsten Wittwer, Fabio De Robertis, Toufan Bahrami, Mohamed Amrani, André R. Simon. European Journal of Cardio-Thoracic Surgery (2016). DOI:https://doi.org/10.1093/ejcts/ezv051.
Utilization of the Organ Care System – A Game-Changer in Combating Donor Organ Shortage
Aron-Frederik Popov, Diana García Sáez, Anton Sabashnikov, Nikhil P. Patil, Mohamed Zeriouh, Prashant N. Mohite, Bartlomiej Zych, Bastian Schmack, Arjang Ruhparwar, Klaus Kallenbach, Pascal M. Dohmen, Matthias Karc, Andre R. Simon, Alexander Weymann. Medical Science Monitor Basic Research (2015). DOI:10.12659/MSMBR.894020.
Utilization of the organ care system for bilateral lung transplantation: preliminary results of a comparative study
Mohamed Zeriouh, Anton Sabashnikov, Prashant N. Mohite, Bartlomiej Zych, Nikhil P. Patil, Diana García-Sáez, Achim Koch, Alexander Weymann, Simona Soresi, Jens Wippermann, Thorsten Wahlers, Fabio De Robertis, Aron-Frederik Popov, André R. Simon. Perfusion (2016). DOI:https://doi.org/10.1093/icvts/ivw135
HEART
Jacob N. Schroder MD, Chetan B. Patel MD, Adam D. DeVore MD, MHS, Sarah Casalinova BS, Kevin J. Koomalsingh MD, Ashish S. Shah MD, Anelechi C. Anyanwu MD, David A. D’Alessandro MD, Karol Mudy MD, Benjamin Sun MD, Martin Strueber MD, Asghar Khaghani MD, Yasuhiro Shudo MD, PhD, Fardad Esmailian MD, Kenneth Liao MD, PhD, Francis D. Pagani MD, PhD, Scott Silvestry MD, I-wen Wang MD, PhD, Christopher T. Salerno MD, Tarek S. Absi MD, Joren C. Madsen MD, DPhil, Donna Mancini MD, Amy G. Fiedler MD, Carmelo A. Milano MD, Jason W. Smith MD. JACC: Heart Failure (2023). doi.org/10.1016/j.jchf.2023.11.015.
Transplantation Outcomes with Donor Hearts after Circulatory Death
Jacob N. Schroder, M.D., Chetan B. Patel, M.D., Adam D. DeVore, M.D., Benjamin S. Bryner, M.D., Sarah Casalinova, B.S., Ashish Shah, M.D., Jason W. Smith, M.D., Amy G. Fiedler, M.D., Mani Daneshmand, M.D., Scott Silvestry, M.D., Arnar Geirsson, M.D., Victor Pretorius, M.B., Ch.B.,et al. The New England Journal of Medicine (2023). DOI: 10.1056/NEJMoa2212438.
Short-term outcomes after heart transplantation using donor hearts preserved with ex vivo perfusion
William Herrik Nielsen, Finn Gustafsson, Peter Skov Olsen, Peter Bo Hansen, Kasper Rossing, Nikolaj Bang Lilleør, Peter Hasse Møller-Sørensen & Christian Holdflod Møller. Scandinavian Cardiovascular Journal (2023). DOI:https://doi.org/10.1080/14017431.2023.2267804.
Jacob N. Schroder MD, Chetan B. Patel MD, Adam D. DeVore MD, MHS, Sarah Casalinova BS, Kevin J. Koomalsingh MD, Ashish S. Shah MD, Anelechi C. Anyanwu MD, David A. D’Alessandro MD, Karol Mudy MD, Benjamin Sun MD, Martin Strueber MD, Asghar Khaghani MD, Yasuhiro Shudo MD, PhD, Fardad Esmailian MD, Kenneth Liao MD, PhD, Francis D. Pagani MD, PhD, Scott Silvestry MD, I-wen Wang MD, PhD, Christopher T. Salerno MD, Tarek S. Absi MD, Joren C. Madsen MD, DPhil, Donna Mancini MD, Amy G. Fiedler MD, Carmelo A. Milano MD, Jason W. Smith MD. JACC: Heart Failure (2023). doi.org/10.1016/j.jchf.2023.11.015.
Transplantation Outcomes with Donor Hearts after Circulatory Death
Jacob N. Schroder, M.D., Chetan B. Patel, M.D., Adam D. DeVore, M.D., Benjamin S. Bryner, M.D., Sarah Casalinova, B.S., Ashish Shah, M.D., Jason W. Smith, M.D., Amy G. Fiedler, M.D., Mani Daneshmand, M.D., Scott Silvestry, M.D., Arnar Geirsson, M.D., Victor Pretorius, M.B., Ch.B.,et al. The New England Journal of Medicine (2023). DOI: 10.1056/NEJMoa2212438.
Short-term outcomes after heart transplantation using donor hearts preserved with ex vivo perfusion
William Herrik Nielsen, Finn Gustafsson, Peter Skov Olsen, Peter Bo Hansen, Kasper Rossing, Nikolaj Bang Lilleør, Peter Hasse Møller-Sørensen & Christian Holdflod Møller. Scandinavian Cardiovascular Journal (2023). DOI:https://doi.org/10.1080/14017431.2023.2267804.
Ameesh Isath, MBBS, Suguru Ohira, MD, PhD, Avi Levine, MD, Stephen Pan, MD, Chhaya Aggarwal-Gupta, MD, Gregg M. Lanier, MD, Kevin Wolfe, PhD, David Spielvogel, MD, Alan Gass, MD, and Masashi Kai, MD. Transplant Direct (2023). DOI:10.1097/TXD.0000000000001455.
J.N. Schroder, D. D'Alessandro, F. Esmailian, T. Boeve, P. Tang, K. Liao, I. Wang, A. Anyanwu, A. Shah, K. Mudy, E. Soltesz, J.W. Smith. Journal of Heart and Lung Transplantation (2019). DOI:https://doi.org/10.1016/j.healun.2019.01.088.
S.V. Rojas, F. Ius, D. Schibilsky, T. Kaufeld, W. Sommer, C. Benk, T. Goecke, T. Siemeni, R. Poyanmehr, S. Rümke, A. Mogaldea, D. Bobylev, J. Salman, M. Avsar, I. Tudorache, C. Bara, F. Beyersdorf, A. Haverich, M. Siepe, G. Warnecke. Journal of Heart and Lung Transplantation (2019). DOI:https://doi.org/10.1016/j.healun.2019.01.091.
S. Messer, A. Page, M. Berman, S. Colah, J. Dunning, E. Pavlushkov, P. Kaul, J. Parameshwar, Y. Abu-Omar, S. Pettit, C. Lewis, A. Kydd, S. Bhagra, A. Cockell, R. Quigley, J. Baxter, C. Ellis, D. Jenkins, C. Sudarshan, A. Ali, S. Tsui, P. Catarino, S. Large. Journal of Heart and Lung Transplantation (2019). DOI:https://doi.org/10.1016/j.healun.2019.01.090.
S. Sponga, V. Ferrara, A.P. Beltrami, A. Bonetti, C. Cantarutti, A. Caragnano, F. Ortolani, A. Lechiancole, R. Esposito, C. Di Nora, V. Tursi, C. Nalli, U. Livi. Journal of Heart and Lung Transplantation (2019). DOI:https://doi.org/10.1016/j.healun.2019.01.089.
Waleed H. Hassanein, MD, Lambros Zellos, MD, Tracey A. Tyrrell, BA, Nancy A. Healey, BS, Michael D. Crittenden, MD, Vladimir Birjiniuk, MD, Shukri F. Khuri, MD. Journal of Thoracic and Cardiovascular Surgery (1998). DOI:https://doi.org/10.1016/S0022-5223(98)00452-8.
Organ Preservation with the Organ Care System
R. Yeter, M. Hübler, M. Pasic, R. Hetzer, C. Knosalla. Applied Cardiopulmonary Pathophysiology (2012). CorpusID:27502592.
Evaluation of the Organ Care System in Heart Transplantation With an Adverse Donor/Recipient Profile
Diana García Sáez, MD, Bartlomiej Zych, MD, Anton Sabashnikov, MD, Christopher T. Bowles, PhD, Fabio De Robertis, MD, Prashant N. Mohite, MD, Aron-Frederik Popov, MD, PhD, Olaf Maunz, CCP, Nikhil, P. Patil, MRCS, MCh, Alexander Weymann, MD, Timothy Pitt, CCP, Louise McBrearty, CCP, Bradley Pates, CCP, Rachel Hards, RN, Mohamed Amrani, MD, PhD, Toufan Bahrami, MD, Nicholas R. Banner, MD, PhD, Andre R. Simon, MD, PhD. Annals of Thoracic Surgery (2014). DOI:https://doi.org/10.1016/j.athoracsur.2014.06.098.
Successful Heart Transplant after Ten Hours Out-of-body Time using the TransMedics Organ Care System