BETTER CLINICAL OUTCOMES AND LOWER COST OF CARE

TransMedics' Organ Care System is a unique investigational technology designed to maintain organs in a warm, functioning state outside of the body to optimize their health and allow continuous clinical evaluation. By pumping warm, oxygenated, nutrient-rich blood through the organ from the time of removal until it is implanted, the organ may withstand longer periods of time outside of the body and suffer less damage during transportation to the recipient.

Current cold preservation (ischemic) methods for organ transportation create severe time limitations, as well as injury to the organ, resulting in significant underutilization of the current pool of consented, donated organs.

The Organ Care System maintains organs
in a "living" functional state outside the body.

The first use of the Organ Care System is for heart transplant. The Organ Care System was developed to reduce the ischemic injury experienced by the organ and to provide surgeons the unique opportunity to assess and potentially improve an organ's function prior to transplant.

By decreasing the risk of post-surgical complications and increasing the number of transplantable organs, the Organ Care System could potentially provide significant cost benefits to the healthcare system, including:

• Reducing the period of time patients need to be maintained on costly bridge therapies while waiting for a donor organ
• Enabling more rapid recovery and reduced hospital stays following transplantation
• Reducing need for medical therapy to treat complications
• Reducing need for re-transplantation

The Organ Care System has undergone years of extensive testing in consultation with some of the world’s leading transplant surgeons. Clinical studies for additional types of organs, in addition to the heart, are currently under development.